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首都医科大学附属北京天坛医院

北京市免疫试剂临床工程技术研究中心

科研成果

字号: + - 14

      北京市免疫试剂临床工程技术研究中心结合依托单位的学科特点和资源优势,围绕神经系统疾病,不断凝练研究方向,充实研究内容,搭建了神经系统疾病相关分子生物学、蛋白质组学、细胞形态学实验诊断平台,建立了神经系统疾病标志物研究的方向,开展了一系列个体化诊断及治疗策略的相关研究。中心针对基于抗体开发的高通量检测技术,结合酶联免疫吸附试验的低成本、化学发光的高灵敏和自动化、芯片技术的多指标联合检测等特点,进行了一系列技术开发及临床应用研究,旨在为疾病诊断提供快速、高效、经济的技术支持。

(一)以北京市免疫试剂临床工程技术研究中心为完成单位,发表SCI及核心期刊文章60余篇,代表作如下:

1.Zheng G, Zhang C, Zhang G, et al. Evaluation of the Diagnostic and Prognostic Value of CSF Presepsin Levels in Patients with Postneurosurgical Ventriculitis/Meningitis. Infect Drug Resist, 2021,14: 2901-2909

2.Shi Y, Ding Y, Li G, et al. Discovery of Novel Biomarkers for Diagnosing and Predicting the Progression of Multiple Sclerosis Using TMT-Based Quantitative Proteomics. Front Immunol. 2021, 12:700031

3.Hong L, Hongmei W, Leijie X, et al. Serum ceramide concentrations are associated with depression in patients after ischemic stroke-A two-center case-controlled study. Clin Chim Acta. 2021, 518:110-115

4.Chenxi Zhang, Ying Han, Bo Sun, et al. Label‐free serum detection based on Raman spectroscopy for the diagnosis and classification of glioma. Journal of Raman Spectroscopy, 2020, 51(10): p. 1977-1985

5.Xiangrui Meng, Guojun Zhang, Bo Sun, et al. Rapid Detection of mecA and femA Genes by Loop-Mediated Isothermal Amplification in a Microfluidic System for Discrimination of Different Staphylococcal Species and Prediction of Methicillin Resistance. Frontiers in Microbiology, 2020. 11: p. 1487

6.Liu S, Zhu Y, Zhang C, et al. The Clinical Significance of Soluble Programmed Cell Death-Ligand 1 (sPD-L1) in Patients With Gliomas. Frontiers in Oncology, 2020, 23, 10: 9

7.Limin Zhang, Xingang Li, Dongzhi Wang, et al. Risk Factors of Recurrent Ischemic Events after Acute Noncardiogenic Ischemic Stroke. Current Pharmaceutical Design, 2020. 25(45): 4827-4834

8.Shi Y, Zheng G, Qian L, et al. Longitudinal Analysis of Risk Factors for Clinical Outcomes of Enterobacteriaceae Meningitis/Encephalitis in Post-Neurosurgical Patients: A Comparative Cohort Study During 2014–2019. Infect Drug Resist. 2020;13:2161-2170

9.Zhang L, Lv H, Zhang Q, et al. Association of SLCO1B1 and ABCB1 Genetic Variants with Atorvastatin-induced Myopathy in Patients with Acute Ischemic Stroke. Curr Pharm Des. 2019;25(14):1663-1670. ISSN: 1381-6128

10.Hui Zhao, Miao Ma , Limin Zhang, et al. Diagnosis of central nervous system lymphoma via cerebrospinal fluid cytology: a case report. BMC Neurology, 2019 May 7;19(1):90

11.RuiminMa, GuanghuiZheng, ChunqingShao, et al. Downregulation of miR-196b Promotes Glioma Cell Sensitivity to Temozolomide Chemotherapy and Radiotherapy. Annals of Clinical & Laboratory Science, 48(6), 2018: 719-725

12.Ming Gao, Bin Zhu, Ping Li,Guojun Zhang, Kelin Chen, Hong Lv, Ruimin Ma, Limin Zhang, Yubo Fan, Xixiong Kang*. Influence of the IGFBP3-202A/C Gene Polymorphism on Clinical Features and Surgery Outcome in Acromegalic Patients. Frontiers in Endocrinology. 2018, 9:751

13.Ming Gao, Bin Zhu, Zhe Xu, et al. Association between acromegaly and a single nucleotide polymorphism (rs2854744)in the IGFBP3 gene. BMC Medical Genetics.2018, 19(1):182

14.MENG WANG, GUOJUN ZHANG, YAJIE WANG, et al.DHX32 expression is an indicator of poor breast cancer prognosis. ONCOLOGY LETTERS, 2017, 13: 942-948

15.MARUIMIN, KXX*,ZGJ*.High expression of UBE2C is associated with the aggressive progression and poor outcome of malignant glioma. Oncol Lett. 2016, 11(3):2300-2304, 1792-1074.

 (二) 承担多项国家级、省部级及企业委托课题,代表如下:

1.“扬帆”计划重点医学专业-神经感染实验诊断”,省部级,负责人:张国军

2.“国产全自动化学发光免疫分析系统验评与推广”,省部级,负责人:张国军

3.“传染病新型诊断试剂及配套仪器的研制”, “艾滋病和病毒性肝炎等重大传染病防治”科技重大专项,国家级,负责人:张国军

4. “基于微流控碟式芯片技术平台的新型传染病分子诊断试剂、配套设备等产品研究开发”,国家级,“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项,负责人:吕虹

5. “便携移动式新型冠状病毒(2019-nCov)检测技术与产品研发“国家重点研发计划项目,负责人:吕虹

6.关于弱磁定量检测神经元烯醇化酶(NSE)的联合开发协议,企业委托,负责人:张国军

7.神经系统感染相关因子的化学发光多联免疫系统研制,北京市科委,负责人:张国军

8.迈瑞检测系统CL2000i及配套试剂盒的临床评估,企业委托,负责人:张国军

(三)人才

北京市免疫试剂临床工程技术研究中心十分重视青年人才的引进及培养工作,自成立以来,针对各个研究方向的发展需要,平均每年均引进2~3名研究生学历的青年人才,结合各自的专业背景和研究特长,进行了个性化的培养。近年来,中心也获批了多个人才培养项目,包括北京市优秀人才青年拔尖个人(马瑞敏)、北京市优秀人才青年骨干(郑光辉)、北京市科协青年人才托举工程(郑光辉)、北京天坛医院“苗圃工程”(徐婷)、北京市医管局“青苗”计划(王玉飞)、北京市医管局“青苗”计划(郑光辉)、北京市医管局培育计划(郑光辉)等。


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